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. 2009 Nov 15;8(22):3777-81.
doi: 10.4161/cc.8.22.10121. Epub 2009 Nov 23.

Cellular quiescence caused by the Mdm2 inhibitor nutlin-3A

Lioubov G Korotchkina  1 , Zoya N Demidenko, Andrei V Gudkov, Mikhail V Blagosklonny
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Cellular quiescence caused by the Mdm2 inhibitor nutlin-3A

Lioubov G Korotchkina et al. Cell Cycle. .

Abstract

Cellular senescence is characterized by irreversible loss of proliferative potential and a large, flat cell morphology. Ectopic p21 and doxorubicin induced cellular senescence in HT1080 and WI-38-tert cell lines. In the same cell lines, the Mdm2 inhibitor nutlin-3a induced p53 but, unexpectedly, caused quiescence (reversible arrest) with a small cell morphology. We discuss that Mdm antagonists could be used in combination with chemotherapy to reversibly arrest normal cells, thus protecting them during chemotherapy of cancer (cyclotherapy).

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