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Multicenter Study
. 2010 Jun-Jul;19(5):310-8.
doi: 10.1097/IJG.0b013e3181b6e5cd.

Optic nerve head (ONH) topographic analysis by stratus OCT in normal subjects: correlation to disc size, age, and ethnicity

Barbara C Marsh  1 , Louis B Cantor, Darrell WuDunn, Joni Hoop, Jennifer Lipyanik, Vincent Michael Patella, Donald L Budenz, David S Greenfield, Jonathan Savell, Joel S Schuman, Rohit Varma
Affiliations
Multicenter Study

Optic nerve head (ONH) topographic analysis by stratus OCT in normal subjects: correlation to disc size, age, and ethnicity

Barbara C Marsh et al. J Glaucoma. 2010 Jun-Jul.

Abstract

Purpose: To study optic nerve head (ONH) topography parameters measured by Stratus optical coherence tomography (OCT) in normal subjects and to analyze ONH data for differences in relation to disc size, ethnicity, and age.

Methods: Three hundred sixty-seven normal subjects underwent Stratus optical coherence tomography ONH measurement using the fast optic disc scan protocol software package 3.0. Only ONH scans meeting specific qualification criteria were included for data analysis ensuring appropriate scan quality and reliability. ONH topographic parameters of qualified scans were analyzed for differences in regards to optic disc size, age, and ethnicity.

Results: Two hundred and twelve qualified ONH scans were included for data analysis. Mean disc area was 2.27+/-0.41 mm and optic cup area, rim area, and horizontal integrated rim width increased with disc size, whereas vertical integrated rim area did not. Vertical integrated rim area, horizontal integrated rim width, and rim area decreased and cup area increased with age. Mean optic disc area was larger in African-Americans as compared with Hispanics or Whites and this difference was statistically significant.

Conclusions: Optic cup area, rim area, and horizontal integrated rim width correlated to disc size. Vertical integrated rim area, horizontal integrated rim width, rim area, and cup area, changed with age. African-American optic discs had larger disc area measurements as compared with Whites optic discs and this difference was statistically significant.

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Figures

FIGURE 1
FIGURE 1
ONH scan qualification. The ONH scan shown on the right was disqualified from inclusion in the study due to difficulty of the automated algorithm to reliably recognize the optic disc margin. This is evident by multiple disc margin reference points separated from the disc outline. OD indicates right eye; ONH optic nerve head; OS, left eye.
FIGURE 2
FIGURE 2
Disc area distribution for the 212 qualified automated scans.
FIGURE 3
FIGURE 3
Optic cup area (mm2) and rim area (mm2) in relation to overall disc size for the 212 qualified automated scans. Measurements of optic cup area and rim area increase with larger disc size. Stratus OCT determines optic cup area independent from disc area, whereas optic rim area is deduced directly from disc area and cup area.
FIGURE 4
FIGURE 4
Vertical integrated (vert. integ.) rim area and horizontal integrated (horiz. integ.) rim width in relation to optic disc area for the 212 qualified automated scans. Measurements of horizontal integrated rim width increase with larger disc size.
FIGURE 5
FIGURE 5
Disc area, cup area, and rim area were analyzed in relation to age. Cup area increased with age and rim area decreased with age.
FIGURE 6
FIGURE 6
Horizontal integrated (horiz. integ.) rim width and vertical integrated (vert. integ.) rim area were analyzed in relation to age. Horizontal integrated rim width and vertical integrated rim area decrease with age.
See this image and copyright information in PMC

References

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