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. 2009 Nov 19;11(22):5314-7.
doi: 10.1021/ol902279m.

Four-component reactions toward fused heterocyclic rings

Etienne Airiau  1 , Nicolas Girard, André Mann, Jessica Salvadori, Maurizio Taddei
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Four-component reactions toward fused heterocyclic rings

Etienne Airiau et al. Org Lett. .

Abstract

A multicomponent reaction between H(2), CO, an unsaturated carboxylic acid derivative, and binucleophiles has been discovered. This process represents a combination of diversity-oriented synthesis and multicomponent reactions including amidation and hydroformylation, followed by nucleophilic addition to an N-acyliminium ion allowing the generation of six new bonds. Using pi-nucleophiles, the sequence turns into a multicomponent Pictet-Spengler reaction.

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