doi: 10.1093/jnci/59.5.1561.
High incidence of ependymomas induced by BK virus, a human papovavirus: brief communication
- PMID: 198571
- DOI: 10.1093/jnci/59.5.1561
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High incidence of ependymomas induced by BK virus, a human papovavirus: brief communication
J Natl Cancer Inst.
1977 Nov.
Abstract
Ependymomas were produced in 44 of 50 Syrian golden hamsters and in 9 of 31 outbred Swiss mice inoculated intracerebrally with high-titer, purified BK virus (BKV). Tumors contained a T-antigen that reacted with BKV-specific T-antibody in immunofluorescence and complement-fixation tests. A proportion of tumor-bearing animals had antibodies to BKV T-antigen in their sera. BKV could be rescued from two tumor cell lines by Sendal virus-mediated fusion with Vero cells. A low, or lack of, oncogenic activity was displayed by BKV inoculated sc, ip, or iv.
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