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. 2010 Jan;88(1):1-2.
doi: 10.1038/icb.2009.82. Epub 2009 Oct 27.

Nef, macrophages and B cells: a highway for evasion

Susan Moir, Anthony S Fauci

Nef, macrophages and B cells: a highway for evasion

Susan Moir et al. Immunol Cell Biol. 2010 Jan.
No abstract available

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Figures

Figure 1
Figure 1
Schematic of the inhibitory effects of Nef on follicular B cells. Nef delivered to B cells from infected macrophages in germinal center (GC) inhibits CD40-mediated class switching to immunoglobulin (Ig)A and IgG2. In contrast, B cells in extrafollicular areas of low Nef expression undergo polyclonal activation in response to increased levels of ferritin and the B-cell activating factor of the tumor necrosis factor family.
See this image and copyright information in PMC

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