Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2009 Oct;6(10):e1000169.
doi: 10.1371/journal.pmed.1000169. Epub 2009 Oct 27.

Antiretroviral strategies to prevent mother-to-child transmission of HIV: striking a balance between efficacy, feasibility, and resistance

Dara A Lehman  1 , Grace C John-Stewart, Julie Overbaugh
Affiliations
Comment

Antiretroviral strategies to prevent mother-to-child transmission of HIV: striking a balance between efficacy, feasibility, and resistance

Dara A Lehman et al. PLoS Med. 2009 Oct.

Abstract

Dara Lehman and colleagues discuss a randomized trial that found that adding up to a week of twice-daily zidovudine+lamivudine to single-dose nevirapine reduces the risk of resistance in mothers and infants.

PubMed Disclaimer

Conflict of interest statement

The authors have declared that no competing interests exist.

Comment on

References

    1. World Health Organization. Antiretroviral drugs for treating pregnant women and preventing HIV infection in infant: towards universal access. Recommendations for a public health approach. 2006. Available: http://www.who.int/hiv/pub/guidelines/pmtctguidelines3.pdf. Accessed 4 September 2009. - PubMed
    1. Guay LA, Musoke P, Fleming T, Bagenda D, Allen M, et al. Intrapartum and neonatal single-dose nevirapine compared with zidovudine for prevention of mother-to-child transmission of HIV-1 in Kampala, Uganda: HIVNET 012 randomised trial. Lancet. 1999;354:795–802. - PubMed
    1. Arrive E, Dabis F. Prophylactic antiretroviral regimens for prevention of mother-to-child transmission of HIV in resource-limited settings. Curr Opin HIV AIDS. 2008;3:161–165. - PMC - PubMed
    1. Jourdain G, Ngo-Giang-Huong N, Le Coeur S, Bowonwatanuwong C, Kantipong P, et al. Intrapartum exposure to nevirapine and subsequent maternal responses to nevirapine-based antiretroviral therapy. N Engl J Med. 2004;351:229–240. - PubMed
    1. Lockman S, Shapiro RL, Smeaton LM, Wester C, Thior I, et al. Response to antiretroviral therapy after a single, peripartum dose of nevirapine. N Engl J Med. 2007;356:135–147. - PubMed

MeSH terms