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. 2009 Oct;15(10):1668-70.
doi: 10.3201/eid1510.081668.

West Nile virus infection in plasma of blood and plasma donors, United States

Christina B Planitzer  1 , Jens Modrof, Mei-ying W Yu, Thomas R Kreil
Affiliations

West Nile virus infection in plasma of blood and plasma donors, United States

Christina B Planitzer et al. Emerg Infect Dis. 2009 Oct.

Abstract

This study investigated the association of ongoing West Nile virus (WNV) infections with neutralizing antibody titers in US plasma-derived intravenous immune globulin released during 2003-2008. Titers correlated closely with the prevalence of past WNV infection in blood donors, with 2008 lots indicating a prevalence of 1%.

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Figures

Figure 1
Figure 1
West Nile virus (WNV) neutralization titers of US plasma-derived immune globulin intravenous (human) (IGIV) lots by year of production and estimated percentage of the US population with past WNV infection by year. WNV neutralization titers were determined either for retention or lot release samples of 3 IGIV products produced during 1998–2005 or for a considerable proportion of Gammagard Liquid/KIOVIG lots produced during 2006–2008. Results are shown as mean ± SEM (limit of detection <0.8) by year of product release. For 5% of IGIV samples, titers were multiplied by 2 for comparison with the 10% IGIV samples at equivalent immunoglobulin concentrations. The percentage of the US donor population with past WNV infection was calculated from the number of neuroinvasive cases reported per year and the estimated ratio of neuroinvasive cases to total cases of WNV infection.
Figure 2
Figure 2
West Nile virus (WNV) neutralization by US plasma-derived immune globulin intravenous (human) (IGIV) released in 2008 and plasma from donors with past WNV infection (past WNV), confirmed by nucleic acid testing. WNV neutralization titers are shown as the mean ± SEM (limit of detection <0.8 for undiluted IGIVs and <7.7 for prediluted sera). NT50, 50% neutralization titer.
See this image and copyright information in PMC

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