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. 2009 Oct;15(10):1677-80.
doi: 10.3201/eid1510.090563.

Independent lineage of lymphocytic choriomeningitis virus in wood mice (Apodemus sylvaticus), Spain

Juan Ledesma  1 , Cesare Giovanni Fedele, Francisco Carro, Lourdes Lledó, María Paz Sánchez-Seco, Antonio Tenorio, Ramón Casimiro Soriguer, José Vicente Saz, Gerardo Domínguez, María Flora Rosas, Jesús Félix Barandika, María Isabel Gegúndez
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Independent lineage of lymphocytic choriomeningitis virus in wood mice (Apodemus sylvaticus), Spain

Juan Ledesma et al. Emerg Infect Dis. 2009 Oct.

Abstract

To clarify the presence of lymphocytic choriomeningitis virus (LCMV) in Spain, we examined blood and tissue specimens from 866 small mammals. LCMV RNA was detected in 3 of 694 wood mice (Apodemus sylvaticus). Phylogenetic analyses suggest that the strains constitute a new evolutionary lineage. LCMV antibodies were detected in 4 of 10 rodent species tested.

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Figures

Figure
Figure
Phylogeny of lymphocytic choriomeningitis virus (LCMV) strains and the viruses detected in this study based on the analysis of complete sequences of amino acids (aa) and nucleotides (nt) of glycoprotein (GPC) and nucleocapsid protein (NP) genes. A) GPC nt; B) GPC aa; C) NP nt; D) NP aa. Each sequence used shows the name of LCMV strain followed by GenBank accession number. Numbers indicate >80% bootstrap values. Scale bars indicate nucleotide substitutions per site. IPPIV, Ippy virus; LASV, Lassa virus; MOBV, Mobala virus; MOPV; Mopeia virus.
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