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. 2009 Nov 5;11(21):4874-7.
doi: 10.1021/ol901946h.

Benzosceptrins A and B with a unique benzocyclobutane skeleton and nagelamide S and T from Pacific sponges

Jérôme Appenzeller  1 , Supriya Tilvi, Marie-Thérèse Martin, Jean-François Gallard, Hoda El-bitar, Elise Tran Huu Dau, Cécile Debitus, Dominique Laurent, Céline Moriou, Ali Al-Mourabit
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Benzosceptrins A and B with a unique benzocyclobutane skeleton and nagelamide S and T from Pacific sponges

Jérôme Appenzeller et al. Org Lett. .

Abstract

Four new dimeric pyrrole-2-aminoimidazole alkaloids have been isolated from the Pacific marine sponges Agelas cf. mauritiana and Phakellia sp. They include the unusual C2 symmetrical benzosceptrins A (4) and B (5), which each possess a unique benzocyclobutane skeleton and nagelamides S (6) and T (7). Their structures and relative configuration were elucidated from spectroscopic data. Plausible biogenetic paths for these compounds are also proposed in this paper.

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