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Comparative Study
. 1991 Jan 1;41(1):115-8.
doi: 10.1016/0006-2952(91)90018-z.

A prenylflavone, artonin E, as arachidonate 5-lipoxygenase inhibitor

G R Reddy  1 , N Ueda, T Hada, A C Sackeyfio, S Yamamoto, Y Hano, M Aida, T Nomura
Affiliations
Comparative Study

A prenylflavone, artonin E, as arachidonate 5-lipoxygenase inhibitor

G R Reddy et al. Biochem Pharmacol. .

Abstract

Several naturally occurring prenylflavones were tested for their inhibitory actions on arachidonate 5-lipoxygenase purified from porcine leukocytes. Of the compounds tested, artonin E (5'-hydroxymorusin) exhibited the most potent inhibition on arachidonate 5-lipoxygenase (IC50 = 0.36 microM). Arachidonate 12-lipoxygenase purified from porcine leukocytes and human platelets, 15-lipoxygenase from rabbit reticulocytes and fatty acid cyclooxygenase from bovine vesicular glands were inhibited by the compound only at higher concentrations (IC50 = 2.3, 11, 5.2 and 2.5 microM, respectively).

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