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. 1991 Jan 1;41(1):37-41.
doi: 10.1016/0006-2952(91)90008-s.

Butyrylcholinesterase and acetylcholinesterase prophylaxis against soman poisoning in mice

Y Ashani  1 , S Shapira, D Levy, A D Wolfe, B P Doctor, L Raveh
Affiliations

Butyrylcholinesterase and acetylcholinesterase prophylaxis against soman poisoning in mice

Y Ashani et al. Biochem Pharmacol. .

Abstract

Human butyrylcholinesterase (BChE, EC 3.1.1.8) or acetylcholinesterase (AChE, EC 3.1.1.7) from fetal bovine serum (FBS), administered i.v. in mice, sequestered at approximately 1:1 stoichiometry the highly toxic anti-ChE organophosphate, 1,2,2-trimethylpropyl methyl-fluorophosphonate (soman). A quantitative linear correlation was demonstrated between blood-ChE levels and the protection conferred by exogeneously administered ChE. Results presented here demonstrate that either human BChE or FBS-AChE is an effective prophylactic measure sufficient to protect mice from multiple LD50S of soman without the administration of post-treatment supportive drugs.

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