Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1917 Oct 1;26(4):453-75.
doi: 10.1084/jem.26.4.453.

THE NEUTRALIZATION OF ANTIPNEUMOCOCCUS IMMUNE BODIES BY INFECTED EXUDATES AND SERA

R Cole  1
Affiliations

THE NEUTRALIZATION OF ANTIPNEUMOCOCCUS IMMUNE BODIES BY INFECTED EXUDATES AND SERA

R Cole. J Exp Med. .

Abstract

1. In empyema fluids resulting from infection with pneumococci there are present large amounts of soluble substances which have the property of neutralizing pneumococcus antibodies. 2. Similar substances are found in the blood of infected rabbits. 3. When immune serum is injected into infected rabbits the immune substances disappear very quickly, and therefore are prevented from activity in overcoming the infection. 4. When immune serum is administered to patients severely infected with pneumococci, the immune bodies may also disappear very rapidly, and this disappearance is probably associated with the presence of such soluble substances in the blood. 5. The serum only becomes effective when these substances are neutralized. 6. The study of agglutination curves is of value in showing why in certain instances favorable results have not followed the use of immune serum. 7. It is important that in severely injected patients the serum be administered early in the disease and that the initial dosage be large.

PubMed Disclaimer

References

    1. J Exp Med. 1912 Nov 1;16(5):665-79 - PubMed
    1. J Exp Med. 1915 Oct 1;22(4):457-64 - PubMed
    1. J Exp Med. 1917 Oct 1;26(4):477-93 - PubMed