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. 1921 Aug 31;34(3):245-58.
doi: 10.1084/jem.34.3.245.

STUDIES ON PNEUMOCOCCUS IMMUNITY : I. ACTIVE IMMUNIZATION OF MONKEYS AGAINST PNEUMOCOCCUS TYPE I PNEUMONIA WITH PNEUMOCOCCUS TYPE I VACCINE

R L Cecil  1 , G I Steffen
Affiliations

STUDIES ON PNEUMOCOCCUS IMMUNITY : I. ACTIVE IMMUNIZATION OF MONKEYS AGAINST PNEUMOCOCCUS TYPE I PNEUMONIA WITH PNEUMOCOCCUS TYPE I VACCINE

R L Cecil et al. J Exp Med. .

Abstract

1. The subcutaneous inoculation of monkeys with three large doses of Pneumococcus Type I vaccine confers on them a complete immunity against experimental Pneumococcus Type I pneumonia. 2. The intravenous inoculation of small doses of Pneumococcus Type I vaccine also confers complete immunity against the homologous type of pneumonia. 3. Specific protective bodies may or may not be present in the serum of monkeys vaccinated against Pneumococcus Type I. There appears to be no intimate relation between active immunity against pneumonia and the presence or absence of protective substances in the serum of the vaccinated animal.

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References

    1. J Exp Med. 1920 Mar 31;31(4):403-43 - PubMed
    1. J Exp Med. 1920 Apr 30;31(5):519-53 - PubMed