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. 1927 Sep 30;46(4):645-69.
doi: 10.1084/jem.46.4.645.

THE BIOLOGICAL REACTIONS IN RABBITS TO THE PROTEIN AND PHOSPHATIDE FRACTIONS FROM THE CHEMICAL ANALYSIS OF HUMAN TUBERCLE BACILLI

F R Sabin  1 , C A Doan
Affiliations

THE BIOLOGICAL REACTIONS IN RABBITS TO THE PROTEIN AND PHOSPHATIDE FRACTIONS FROM THE CHEMICAL ANALYSIS OF HUMAN TUBERCLE BACILLI

F R Sabin et al. J Exp Med. .

Abstract

1. The clasmatocyte, the cell with the power of fragmenting tubercle bacilli, the cell making the lesion of the so called interstitial pneumonia, has been shown to be the overwhelming response to the special protein fractions, 304 and 903. Multiple hemorrhages, high fever, and toxicity have marked the use of these fractions in every instance. 2. The epithelioid and the giant cell of the Langhans type, making typical tubercular tissue, have been the massive and specific response of the peritoneal cavity to intraperitoneal injections of the phosphatide fractions, A-3 and A-4. These fractions have been entirely non-toxic in the dosages used.

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References

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