Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1927 Nov 30;46(6):887-907.
doi: 10.1084/jem.46.6.887.

STUDIES ON THE MODE OF SPREAD OF B. ENTERITIDIS MOUSE TYPHOID INFECTION : IV. THE RELATIVE VIRULENCE OF SMOOTH, MUCOID, AND ROUGH STRAINS

L T Webster  1 , C Burn
Affiliations

STUDIES ON THE MODE OF SPREAD OF B. ENTERITIDIS MOUSE TYPHOID INFECTION : IV. THE RELATIVE VIRULENCE OF SMOOTH, MUCOID, AND ROUGH STRAINS

L T Webster et al. J Exp Med. .

Abstract

1. Single cell mouse strains of B. enteritidis from smooth-susceptible colonies were, under the various conditions tested, of the same high degree of virulence. 2 year old cultures, strains obtained both in interepidemic and epidemic periods, and "reverted" strains from variant colonies showed the same degree of pathogenicity. 2. Single cell strains from variant smooth, mucoid,and rough phage-resistant colonies were definitely less virulent than the usual smooth-susceptible strains. The loss of virulence in each instance resulted apparently from contact with bacteriophage which rendered the individual cells incapable of multiplication in the animal tissues. 3. A reduction of virulence was induced experimentally when washed cultures of the highly pathogenic smooth-susceptible cells were exposed to bacteriophage and thus rendered incapable of multiplication in the inoculated animals.

PubMed Disclaimer

References

    1. J Exp Med. 1925 Apr 30;41(5):587-600 - PubMed
    1. J Exp Med. 1927 Jan 31;45(2):353-63 - PubMed