Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1929 May 31;49(6):959-73.
doi: 10.1084/jem.49.6.959.

INTRADERMAL VERSUS SUBCUTANEOUS IMMUNIZATION OF MONKEYS AGAINST POLIOMYELITIS

F W Stewart  1 , C P Rhoads
Affiliations

INTRADERMAL VERSUS SUBCUTANEOUS IMMUNIZATION OF MONKEYS AGAINST POLIOMYELITIS

F W Stewart et al. J Exp Med. .

Abstract

1. The introduction of considerable amounts of living, active poliomyelitis virus into the skin and subcutaneous tissue of monkeys protects the animals against intracerebral inoculations of similar virus material. 2. The degree of protection conferred by intradermal is greater than by subcutaneous injection. 3. During intradermal and subcutaneous inoculations, no local or general pathological signs were observed. 4. The degree of protection produced by the immunization methods used is not absolute, since a percentage of the inoculated monkeys respond to intracerebral injections of highly potent virus. 5. The sera of the animals inoculated intradermally or subcutaneously neutralized poliomyelitis virus in vitro, irrespective of the result of intracerebral inoculation, in all except one instance. 6. The power of the serum of treated monkeys to neutralize virus in vitro is a more delicate test of immunity than is the intracerebral inoculation.

PubMed Disclaimer

References

    1. J Exp Med. 1910 Mar 14;12(2):227-55 - PubMed
    1. J Exp Med. 1929 Mar 31;49(4):701-4 - PubMed