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. 1930 Feb 28;51(3):463-72.
doi: 10.1084/jem.51.3.463.

REACTIONS OF RABBITS TO INTRACUTANEOUS INJECTIONS OF PNEUMOCOCCI AND THEIR PRODUCTS : III. REACTIONS AT THE SITE OF INJECTION

L A Julianelle  1
Affiliations

REACTIONS OF RABBITS TO INTRACUTANEOUS INJECTIONS OF PNEUMOCOCCI AND THEIR PRODUCTS : III. REACTIONS AT THE SITE OF INJECTION

L A Julianelle. J Exp Med. .

Abstract

1. Following repeated intracutaneous injections of heat-killed pneumococci rabbits acquire an increased skin reactivity. 2. The increased skin reactivity reaches a maximum after 4 to 6 injections have been made, after which it becomes greatly diminished. 3. The relationship of increased skin reactivity to active resistance to infection by Pneumococcus, and to the presence of species-specific antibodies in the blood, is still obscure. 4. The increased skin reactivity is not transferable by serum from a highly reactive to a normal rabbit. 5. After regression of the reaction to the first injection of Pneumococcus into the skin, there frequently follows a recrudescence, or exacerbation, of the reaction. 6. The increased skin reactivity and secondary reactions are incited alike by all types and all forms of Pneumococcus.

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References

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