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. 1931 Jan 31;53(2):185-93.
doi: 10.1084/jem.53.2.185.

IMMUNIZATION AGAINST VACCINIA BY NON-INFECTIVE MIXTURES OF VIRUS AND IMMUNE SERUM

C P Rhoads  1
Affiliations

IMMUNIZATION AGAINST VACCINIA BY NON-INFECTIVE MIXTURES OF VIRUS AND IMMUNE SERUM

C P Rhoads. J Exp Med. .

Abstract

1. Vaccine virus and specific immune serum mixed in such proportions as to produce no lesion when inoculated intradermally induce immunity when instilled into the nasal cavities of rabbits. 2. The mixture is also effective when inoculated subcutaneously. 3. Immunity is brought about with a minimum of systemic reaction and no local one. 4. When the mixtures are incompletely neutralized generalized vaccinia results.

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References

    1. J Exp Med. 1929 Aug 31;50(3):341-53 - PubMed