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. 1932 Jan 1;55(1):91-9.
doi: 10.1084/jem.55.1.91.

THE TRANSFORMATION IN VITRO OF R PNEUMOCOCCI INTO S FORMS OF DIFFERENT SPECIFIC TYPES BY THE USE OF FILTERED PNEUMOCOCCUS EXTRACTS

J L Alloway  1
Affiliations

THE TRANSFORMATION IN VITRO OF R PNEUMOCOCCI INTO S FORMS OF DIFFERENT SPECIFIC TYPES BY THE USE OF FILTERED PNEUMOCOCCUS EXTRACTS

J L Alloway. J Exp Med. .

Abstract

1. Avirulent R pneumococci derived from S forms of a specific type may be changed by growth in broth containing anti-R serum and a heated, filtered extract of S pneumococci of a different type, into virulent S organisms identical in type with the bacteria extracted. This has been accomplished in the case of R strains derived from Type II pneumococci, employing extracts prepared from Type III and Type I S forms. 2. The constituents of the extract supply an activating stimulus of a specific nature in that the R pneumococci acquire the capacity of elaborating the capsular material peculiar to the organisms extracted.

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References

    1. J Exp Med. 1930 Jan 1;51(1):123-47 - PubMed
    1. J Exp Med. 1931 Oct 31;54(5):681-99 - PubMed
    1. J Exp Med. 1931 Oct 31;54(5):701-10 - PubMed