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. 1935 Apr 30;61(5):643-56.
doi: 10.1084/jem.61.5.643.

STUDIES ON THE SENSITIZATION OF ANIMALS WITH SIMPLE CHEMICAL COMPOUNDS

K Landsteiner  1 , J Jacobs
Affiliations

STUDIES ON THE SENSITIZATION OF ANIMALS WITH SIMPLE CHEMICAL COMPOUNDS

K Landsteiner et al. J Exp Med. .

Abstract

Experiments on the sensitization of guinea pigs with simple chemical compounds are described. Positive effects were obtained by the administration of small quantities, namely fractions of milligrams, with 1:2:4 chlorodinitrobenzene, p-nitrosodimethylaniline, 1:2:4 trinitrobenzene, picryl chloride, four dichlorodinitrobenzenes, and a number of other aromatic compounds. Several substances chemically similar to those enumerated gave negative results. The first named compound is known to produce hypersensitiveness in human beings, a large number of cases having been observed in factory workers. The mechanism of these effects is discussed.

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References

    1. Science. 1934 Apr 13;79(2050):344 - PubMed
    1. J Exp Med. 1932 Feb 29;55(3):325-51 - PubMed
    1. J Exp Med. 1933 Mar 31;57(4):633-6 - PubMed