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. 1936 Feb 29;63(3):325-39.
doi: 10.1084/jem.63.3.325.

ON CROSS REACTIONS OF IMMUNE SERA TO AZOPROTEINS

K Landsteiner  1 , J van der Scheer
Affiliations

ON CROSS REACTIONS OF IMMUNE SERA TO AZOPROTEINS

K Landsteiner et al. J Exp Med. .

Abstract

The phenomena observed on absorption of immune sera to azoproteins with heterologous azoantigens lead to the conclusion that in general the sera do not contain a single antibody but antibody fractions somewhat different in their reactivity for heterologous antigens. From the constitution of the azocomponent it follows that these fractions cannot be specific for distinct chemical groups in the molecule. In fact, inhibition experiments showed that in the cases examined the various antibodies are all specifically directed towards the whole molecule of the homologous hapten.

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References

    1. J Exp Med. 1924 Jun 30;40(1):91-107 - PubMed
    1. J Exp Med. 1934 May 31;59(6):769-80 - PubMed
    1. J Exp Med. 1935 Oct 31;62(5):697-720 - PubMed