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. 1936 May 31;63(6):795-801.
doi: 10.1084/jem.63.6.795.

PROTHROMBIN DEFICIENCY THE CAUSE OF BLEEDING IN BILE FISTULA DOGS

W B Hawkins  1 , K M Brinkhous
Affiliations

PROTHROMBIN DEFICIENCY THE CAUSE OF BLEEDING IN BILE FISTULA DOGS

W B Hawkins et al. J Exp Med. .

Abstract

The bleeding tendency that develops in bile fistula dogs, completely or partially deprived of bile, is due to a prothrombin deficiency of the blood plasma. However, a relatively low prothrombin level may exist in these animals without the occurrence of spontaneous hemorrhage. The prothrombin level may remain within the limits of normal if sufficient bile has been fed. In these cases no disturbance in blood clotting occurs.

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References

    1. J Exp Med. 1935 Sep 30;62(4):599-620 - PubMed