Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1936 Jul 31;64(2):201-16.
doi: 10.1084/jem.64.2.201.

THE COMPLEMENT FIXATION REACTION WITH PNEUMOCOCCUS CAPSULAR POLYSACCHARIDE

K Goodner  1 , F L Horsfall
Affiliations

THE COMPLEMENT FIXATION REACTION WITH PNEUMOCOCCUS CAPSULAR POLYSACCHARIDE

K Goodner et al. J Exp Med. .

Abstract

1. Complement is not fixed by immune aggregates resulting from the interaction of pneumococcus capsular polysaccharide and type-specific immune horse serum, although under proper conditions the substitution of immune rabbit serum gives positive results. 2. The negative results with immune horse serum are due to some poorly understood property of the specific antibodies rather than to some heterologous inhibitor present in the serum. 3. It has been shown that with immune rabbit serum-polysaccharide combinations, complement fixation is an adsorptive phenomenon conditioned upon the surface exposure of the immune aggregates. 4. A close parallelism to the selective adsorption of phosphatides by these immune aggregates has been pointed out. 5. In those instances in which complement is fixed this phenomenon must be regarded as tertiary and conditioned by (a) union of antigen and antibody, and (b) particulation. 6. The general significance of complement fixation as applied to bacterial polysaccharides has been discussed.

PubMed Disclaimer

References

    1. J Exp Med. 1929 Sep 30;50(4):533-50 - PubMed
    1. J Exp Med. 1929 Nov 30;50(6):809-23 - PubMed
    1. J Exp Med. 1930 Sep 30;52(4):477-83 - PubMed
    1. J Exp Med. 1933 Nov 30;58(6):731-55 - PubMed