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. 1937 Apr 30;65(5):721-34.
doi: 10.1084/jem.65.5.721.

STUDIES ON HAEMOPHILUS INFLUENZAE : I. INFECTION OF MICE WITH MUCIN SUSPENSIONS OF THE ORGANISM

L D Fothergill  1 , J H Dingle, C A Chandler
Affiliations

STUDIES ON HAEMOPHILUS INFLUENZAE : I. INFECTION OF MICE WITH MUCIN SUSPENSIONS OF THE ORGANISM

L D Fothergill et al. J Exp Med. .

Abstract

1. It has been shown that the ability of virulent S. influenzae to kill mice is enhanced by suspending the organism in mucin. 2. The occurrence of a true infection characterized by in vivo multiplication of the organism has been established. 3. The necessity for using a pure inbred strain of mice for this type of study has been confirmed. 4. The increase in mucin virulence of a strain of H. influenzae by repeated passage through mice has been shown. 5. The usefulness of this method in passive immunization studies has been demonstrated.

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References

    1. Science. 1933 Oct 13;78(2024):340-1 - PubMed
    1. J Exp Med. 1931 Mar 31;53(4):471-92 - PubMed
    1. J Exp Med. 1932 Jan 31;55(2):223-34 - PubMed
    1. J Exp Med. 1933 Apr 30;57(5):819-43 - PubMed

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