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. 1938 May 31;67(6):883-910.
doi: 10.1084/jem.67.6.883.

THE FATE OF VACCINIA VIRUS ON CULTIVATION IN VITRO WITH KUPFFER CELLS (RETICULO-ENDOTHELIAL CELLS)

J W Beard  1 , P Rous
Affiliations

THE FATE OF VACCINIA VIRUS ON CULTIVATION IN VITRO WITH KUPFFER CELLS (RETICULO-ENDOTHELIAL CELLS)

J W Beard et al. J Exp Med. .

Abstract

The pathogenic activity of vaccinia virus is in large part suppressed when it is mixed with living Kupffer cells or clasmatocytes in the test-tube and injected intradermally. Vaccinia increases in quantity when introduced into cultures of Kupffer cells in vitro, and survives in immediate association with these elements. No antiviral principle is elaborated by them under such conditions.

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References

    1. Science. 1937 Mar 19;85(2203):292-4 - PubMed
    1. J Exp Med. 1934 Apr 30;59(5):593-607 - PubMed
    1. J Exp Med. 1935 Apr 30;61(5):657-88 - PubMed