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. 1938 May 31;67(6):941-52.
doi: 10.1084/jem.67.6.941.

A METHOD FOR DETERMINING THE DIFFERENTIAL SEDIMENTATION OF PROTEINS IN THE HIGH SPEED CONCENTRATION CENTRIFUGE

T P Hughes  1 , E G Pickels, F L Horsfall
Affiliations

A METHOD FOR DETERMINING THE DIFFERENTIAL SEDIMENTATION OF PROTEINS IN THE HIGH SPEED CONCENTRATION CENTRIFUGE

T P Hughes et al. J Exp Med. .

Abstract

A method is presented for determining the relative degree of sedimentation of proteins and other small particles, either in pure form or in a mixture, utilizing the concentration centrifuge of Bauer and Pickels. Chemical analysis or biological assay of material obtained at different fluid levels by means of a special sampling device is used to measure the degree of sedimentation. The results are reproducible within 10 per cent and, under the conditions of the experiments cited, are characteristic for the proteins thus far investigated.

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References

    1. Biochem J. 1935 Feb;29(2):407-29 - PubMed
    1. Biochem J. 1936 Mar;30(3):528-41 - PubMed
    1. J Exp Med. 1936 Sep 30;64(4):503-28 - PubMed