Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1938 Oct 31;68(6):869-90.
doi: 10.1084/jem.68.6.869.

NORMAL AND PATHOLOGICAL FACTORS INFLUENCING THE SPREAD OF A VITAL DYE IN THE CONNECTIVE TISSUE

R J Parsons  1 , P D McMaster
Affiliations

NORMAL AND PATHOLOGICAL FACTORS INFLUENCING THE SPREAD OF A VITAL DYE IN THE CONNECTIVE TISSUE

R J Parsons et al. J Exp Med. .

Abstract

A method has been devised to measure the spread of vital dyes in the skin of mice. Spread is greatly influenced by physiological and pathological changes which add fluid to the tissue or abstract it. Spread is greater in the quiet, living ear than in the ear of an animal just killed. It is equally considerable in the frankly edematous ears of living and dead animals, and not greater in either case than in normal, quiet tissues. During the early stages of edema formation on the other hand, dye spread is notably rapid. It is still greater in the ears of normal animals actively moving about, and is greatest in tissues subjected to very gently intermittent changes in external pressure. The significance of these findings is discussed.

PubMed Disclaimer

References

    1. J Exp Med. 1932 Jul 31;56(2):223-38 - PubMed
    1. J Exp Med. 1934 Sep 30;60(4):479-501 - PubMed
    1. J Exp Med. 1933 Apr 30;57(5):751-74 - PubMed
    1. J Physiol. 1895 Dec 30;19(1-2):1-14 - PubMed
    1. J Exp Med. 1937 Feb 28;65(3):347-72 - PubMed