Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1939 May 31;69(6):857-66.
doi: 10.1084/jem.69.6.857.

AMOUNT AND DURATION OF IMMUNITY INDUCED BY INTRADERMAL INOCULATION OF CULTURED VACCINE VIRUS

T M Rivers  1 , S M Ward, R D Baird
Affiliations

AMOUNT AND DURATION OF IMMUNITY INDUCED BY INTRADERMAL INOCULATION OF CULTURED VACCINE VIRUS

T M Rivers et al. J Exp Med. .

Abstract

Continued cultivation of vaccine virus in a medium consisting of minced chick embryo tissue and Tyrode's solution has resulted in a virus qualitatively changed to such an extent that considerable amounts of it can be injected intradermally into human beings without danger or inconvenience. Individuals who are vaccinated intradermally with the cultured virus should be revaccinated dermally six months to a year later with a potent calf lymph virus in order to obtain a satisfactory immunity to smallpox without being subjected to the dangers and inconvenience associated with primary vaccinations with calf lymph virus.

PubMed Disclaimer

References

    1. J Exp Med. 1931 Sep 30;54(4):453-61 - PubMed
    1. J Exp Med. 1933 Oct 31;58(5):635-50 - PubMed
    1. J Exp Med. 1935 Sep 30;62(4):549-60 - PubMed