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. 1939 Jul 31;70(2):209-22.
doi: 10.1084/jem.70.2.209.

NEUTRALIZATION OF EPIDEMIC INFLUENZA VIRUS : THE LINEAR RELATIONSHIP BETWEEN THE QUANTITY OF SERUM AND THE QUANTITY OF VIRUS NEUTRALIZED

F L Horsfall  1
Affiliations

NEUTRALIZATION OF EPIDEMIC INFLUENZA VIRUS : THE LINEAR RELATIONSHIP BETWEEN THE QUANTITY OF SERUM AND THE QUANTITY OF VIRUS NEUTRALIZED

F L Horsfall. J Exp Med. .

Abstract

A linear relationship exists between the logarithm of the quantity of epidemic influenza virus neutralized and the logarithm of the quantity of antiserum which is capable of achieving this result. This relationship is the same for the serum of a ferret convalescent from experimental influenza as for the serum of a rabbit immunized with the virus. By means of the linear relationship between virus and antiserum it is possible to determine a fixed, rather than a relative, value for the neutralizing capacity of a serum.

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References

    1. Science. 1934 Nov 16;80(2081):457-9 - PubMed
    1. Am J Public Health Nations Health. 1937 Nov;27(11):1141-60 - PubMed
    1. J Exp Med. 1936 Apr 30;63(5):655-68 - PubMed