Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1940 Jan 1;71(1):43-53.
doi: 10.1084/jem.71.1.43.

A SOLUBLE ANTIGEN OF LYMPHOCYTIC CHORIOMENINGITIS : II. CHARACTERISTICS OF THE ANTIGEN AND ITS USE IN PRECIPITIN REACTIONS

J E Smadel  1 , M J Wall, R D Baird
Affiliations

A SOLUBLE ANTIGEN OF LYMPHOCYTIC CHORIOMENINGITIS : II. CHARACTERISTICS OF THE ANTIGEN AND ITS USE IN PRECIPITIN REACTIONS

J E Smadel et al. J Exp Med. .

Abstract

The soluble antigen of lymphocytic choriomeningitis which is readily separable from the virus is a relatively stable substance and appears to be of a protein nature. A specific precipitin reaction can be demonstrated when immune serum is added to solutions of antigen which have been freed of certain serologically inactive substances. The complement-fixation and precipitation reactions which occur in the presence of immune serum and non-infectious extracts of splenic tissue obtained from guinea pigs moribund with lymphocytic choriomeningitis seem to be manifestations of union of the same soluble antigen and its antibody. On the other hand, the antisoluble substance antibodies and neutralizing substances appear to be different entities.

PubMed Disclaimer

References

    1. J Exp Med. 1939 Jun 30;70(1):53-66 - PubMed
    1. J Exp Med. 1937 Jan 31;65(2):243-9 - PubMed
    1. J Exp Med. 1936 Sep 30;64(4):503-28 - PubMed
    1. J Exp Med. 1936 Jan 1;63(1):69-94 - PubMed
    1. J Exp Med. 1939 Jan 1;69(1):31-48 - PubMed