Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1940 Sep 30;72(4):361-6.
doi: 10.1084/jem.72.4.361.

STUDIES ON THE SENSITIZATION OF ANIMALS WITH SIMPLE CHEMICAL COMPOUNDS : VIII. SENSITIZATION TO PICRIC ACID; SUBSIDIARY AGENTS AND MODE OF SENSITIZATION

K Landsteiner  1 , A A Di Somma
Affiliations

STUDIES ON THE SENSITIZATION OF ANIMALS WITH SIMPLE CHEMICAL COMPOUNDS : VIII. SENSITIZATION TO PICRIC ACID; SUBSIDIARY AGENTS AND MODE OF SENSITIZATION

K Landsteiner et al. J Exp Med. .

Abstract

Sensitization of guinea pigs to picric acid was obtained by application of oil solutions to the skin, preferably on inflamed sites or by treatment with a compound of picric acid with n-butyl-p-aminobenzoate. The lesions obtained in sensitive animals on superficial administration bore resemblance to human eczema. It seems probable that picric acid sensitization is an instance where a substance does not sensitize directly but after conversion into a more reactive compound, a principle which should be of wider application to instances where the original substance does not readily form conjugates.

PubMed Disclaimer

References

    1. J Exp Med. 1936 Sep 30;64(4):625-39 - PubMed
    1. J Exp Med. 1938 Sep 30;68(4):505-12 - PubMed