Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1942 Jul 1;76(1):93-101.
doi: 10.1084/jem.76.1.93.

FUNCTION OF COMPONENTS OF COMPLEMENT IN IMMUNE HEMOLYSIS

L Pillemer  1 , S Seifter, F Chu, E E Ecker
Affiliations

FUNCTION OF COMPONENTS OF COMPLEMENT IN IMMUNE HEMOLYSIS

L Pillemer et al. J Exp Med. .

Abstract

1. At a temperature of 1 degrees C., C'2, C'4, and C'1 combine with sensitized sheep erythrocytes, while C'3 does not combine. 2. C'1, although combining with sensitized cells in the absence of C'4, is hemolytically inert unless C'4 combines previous to, or simultaneously with it. 3. C'4 does not combine in the absence of C'1. 4. Although C'3 is not fixed by antibody-sheep cell aggregates, it is essential for hemolysis, operating on the sensitized red cell after the fixation of C'4, C'2, and C'1 and behaving as if it were a catalyst.

PubMed Disclaimer

References

    1. Science. 1941 Nov 7;94(2445):437 - PubMed
    1. J Exp Med. 1941 Sep 30;74(4):297-308 - PubMed
    1. J Exp Med. 1942 Apr 1;75(4):421-35 - PubMed