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. 1942 Dec 1;76(6):543-56.
doi: 10.1084/jem.76.6.543.

A NATURAL ANTIBODY THAT REACTS IN VITRO WITH A SEDIMENTABLE CONSTITUENT OF NORMAL TISSUE CELLS : I. DEMONSTRATION OF THE PHENOMENON

J G Kidd  1 , W F Friedewald
Affiliations

A NATURAL ANTIBODY THAT REACTS IN VITRO WITH A SEDIMENTABLE CONSTITUENT OF NORMAL TISSUE CELLS : I. DEMONSTRATION OF THE PHENOMENON

J G Kidd et al. J Exp Med. .

Abstract

The foregoing experiments have shown that complement fixation takes place when the blood serum of normal adult rabbits is mixed with fresh saline extracts of normal rabbit tissues under controlled conditions. A natural antibody, which reacts in vitro with a sedimentable constituent of normal tissue cells, is responsible for the phenomenon.

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