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. 1943 May 1;77(5):435-49.
doi: 10.1084/jem.77.5.435.

THE IMMUNOLOGICAL PROPERTIES OF THE HETEROPHILE ANTIGEN AND SOMATIC POLYSACCHARIDE OF PNEUMOCOCCUS

W F Goebel  1 , M H Adams
Affiliations

THE IMMUNOLOGICAL PROPERTIES OF THE HETEROPHILE ANTIGEN AND SOMATIC POLYSACCHARIDE OF PNEUMOCOCCUS

W F Goebel et al. J Exp Med. .

Abstract

1. The lipocarbohydrate or F polysaccharide derived from a rough variant of Type I pneumococcus (I R) is antigenic in rabbits and gives rise to precipitins and sheep cell hemolysins. The somatic or C carbohydrate on the other hand is not antigenic. 2. Antisera for the rough variant of Type 1 pneumococcus contain also bacterial agglutinins immunologically unrelated to the C and F precipitins and the heterophile antibody. 3. A study has been made of the quantitative precipitin reaction of the C and F polysaccharides in the serum of rabbits immunized with the IR pneumococcus clarifying certain of these relationships.

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References

    1. J Exp Med. 1935 Oct 31;62(5):697-720 - PubMed
    1. J Exp Med. 1936 Jan 31;63(2):185-90 - PubMed
    1. J Exp Med. 1937 Mar 31;65(4):487-96 - PubMed