Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1943 May 1;77(5):467-71.
doi: 10.1084/jem.77.5.467.

ANTIGENIC RELATIONSHIP OF BRITISH SWINE INFLUENZA STRAINS TO STANDARD HUMAN AND SWINE INFLUENZA VIRUSES : THE USE OF CHICKEN AND FERRET ANTISERA IN RED CELL AGGLUTINATION

N P Hudson  1 , M M Sigel, F S Markham
Affiliations

ANTIGENIC RELATIONSHIP OF BRITISH SWINE INFLUENZA STRAINS TO STANDARD HUMAN AND SWINE INFLUENZA VIRUSES : THE USE OF CHICKEN AND FERRET ANTISERA IN RED CELL AGGLUTINATION

N P Hudson et al. J Exp Med. .

Abstract

The antigenic relationships of Type A (PR 8, WS) and Type B (Lee) human strains and the Shope and British (Cambridge, North Ireland) swine strains were studied by specific antiserum inhibition of chicken red cell agglutination by the influenza virus. The Cambridge and North Ireland strains were found to be closely related to the Type A strains and differentiated from the Shope virus. The distinctive antigenicity of the Lee strain of Type B was confirmed. Specific antibodies were developed in chickens following single intraperitoneal injections of influenza virus. Inhibition tests yielded results, in the antigenic analysis of the influenza viruses examined, comparable to those obtained with ferret antisera. Specific inhibition of hemagglutination by influenza virus proved an effective method for the study of strain relationships.

PubMed Disclaimer

References

    1. J Exp Med. 1931 Jul 31;54(3):373-85 - PubMed
    1. J Exp Med. 1942 Jan 1;75(1):49-64 - PubMed
    1. Can Med Assoc J. 1936 Jun;34(6):615-22 - PubMed