Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1947 Apr 30;85(5):499-514.
doi: 10.1084/jem.85.5.499.

STUDIES ON THE FLEXNER GROUP OF DYSENTERY BACILLI : VI. THE DETOXIFICATION OF SHIGELLA PARADYSENTERIAE BY MEANS OF PERIODIC ACID

W F Goebel  1
Affiliations

STUDIES ON THE FLEXNER GROUP OF DYSENTERY BACILLI : VI. THE DETOXIFICATION OF SHIGELLA PARADYSENTERIAE BY MEANS OF PERIODIC ACID

W F Goebel. J Exp Med. .

Abstract

A method for detoxifying Type Z and sp. Newcastle Sh. paradysenteriae (Flexner) has been described. This procedure involves exposing the bacilli at pH 5.0 to 0.01 M periodic acid. Microorganisms treated with this reagent for an appropriate time interval lose approximately 90 per cent of their toxicity, yet they are capable of eliciting in experimental animals antibodies effective against the unaltered organisms.

PubMed Disclaimer

References

    1. J Exp Med. 1946 Aug 31;84(3):223-34 - PubMed
    1. J Exp Med. 1920 Jan 1;31(1):19-33 - PubMed
    1. Biochem J. 1941 Nov;35(10-11):1140-63 - PubMed
    1. Science. 1946 Mar 29;103(2674):387-9 - PubMed
    1. J Exp Med. 1946 Jul 31;84(2):143-56 - PubMed