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. 1947 Jul 31;86(2):153-8.
doi: 10.1084/jem.86.2.153.

THE INFLUENCE OF INJECTIONS OF HOMOLOGOUS HEMOGLOBIN ON THE KIDNEYS OF NORMAL AND DEHYDRATED ANIMALS

J J Lalich  1
Affiliations

THE INFLUENCE OF INJECTIONS OF HOMOLOGOUS HEMOGLOBIN ON THE KIDNEYS OF NORMAL AND DEHYDRATED ANIMALS

J J Lalich. J Exp Med. .

Abstract

1. Dehydration, if sufficiently prolonged, favors the accumulation of hemoglobin or its derivatives in the kidneys of rabbits, principally casts formed in the distal convoluted tubules. 2. Once pigment casts have been produced in the distal convoluted tubules, there is obstruction, with atrophy and dilatation of the tubules proximal to the obstruction. 3. When the involvement is sufficiently extensive, there is elevation of the non-protein nitrogen and some animals die because of renal failure.

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References

    1. J Exp Med. 1926 Jan 31;43(2):241-62 - PubMed
    1. J Exp Med. 1945 Oct 31;82(5):361-74 - PubMed