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. 1970 Jul 1;56(1):99-109.
doi: 10.1085/jgp.56.1.99.

The uptake of a labeled double-stranded polynucleotide by cultured rabbit kidney cells: an electron microscopic study

P H Prose  1 , A Friedman-Kien, J Vilcek
Affiliations

The uptake of a labeled double-stranded polynucleotide by cultured rabbit kidney cells: an electron microscopic study

P H Prose et al. J Gen Physiol. .

Abstract

Polyribocytidylate-(3)H-polyriboinosinate (rC-(3)H:rI) enters cultured rabbit kidney cells from the surrounding medium within (1/2) hr after exposure. Grains are found in the cytoplasm, nucleus, and nucleolus. At 2 hr, grains are localized predominantly over the nucleolar regions. Subsequently, the grains in the nucleus become dispersed. A specific receptor site for the initiation of interferon production was not revealed.

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