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. 2009 Nov 19;11(22):5190-3.
doi: 10.1021/ol9021029.

Novel pentacyclic seco-prezizaane-type sesquiterpenoids with neurotrophic properties from Illicium jiadifengpi

Miwa Kubo  1 , Chihiro Okada, Jian-Mei Huang, Kenichi Harada, Hideaki Hioki, Yoshiyasu Fukuyama
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Novel pentacyclic seco-prezizaane-type sesquiterpenoids with neurotrophic properties from Illicium jiadifengpi

Miwa Kubo et al. Org Lett. .

Abstract

Three novel seco-prezizaane-type sesquiterpenoids, jiadifenolide (1), jiadifenoxolane A (2), and jiadifenoxolane B (3), were isolated from the pericarps of Illicium jiadifengpi. Their pentacyclic cage structures were determined by 2D-NMR methods, chemical conversion, and single-crystal X-ray analysis. Compounds 1 and 2 strongly promote neurite outgrowth in primary cultured rat cortical neurons at concentrations ranging from 0.01 to 10 muM.

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