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Comment
. 2009 Oct 30;16(10):1026-7.
doi: 10.1016/j.chembiol.2009.10.003.

Expanding the repertoire of glycosynthases

Lai-Xi Wang  1
Affiliations
Comment

Expanding the repertoire of glycosynthases

Lai-Xi Wang. Chem Biol. .

Abstract

As reported in this issue, Moracci and coworkers have now expanded the glycosynthase concept to two retaining alpha-L-fucosidases. The newly generated alpha-fucosynthases can use beta-L-fucosyl azide as donors for transglycosylation, enabling the synthesis of fucose-containing oligosaccharides.

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Figures

Figure 1
Figure 1
Putative mechanisms for the azide rescuing reaction and the Fucα-1,3-Fucα1-N3 disaccharide formation
Figure 2
Figure 2
Synthesis of fucose-containing oligosaccharides by fucosynthase-catalyzed transglycosylation
See this image and copyright information in PMC

Comment on

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