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. 2009 Nov;32 Suppl 2(Suppl 2):S151-6.
doi: 10.2337/dc09-S301.

Defining and characterizing the progression of type 2 diabetes

Vivian A Fonseca  1
Affiliations

Defining and characterizing the progression of type 2 diabetes

Vivian A Fonseca. Diabetes Care. 2009 Nov.
No abstract available

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Figures

Figure 1
Figure 1
Changes of insulin sensitivity (Si) and acute insulin response to glucose (AIR) from baseline (arrow base) to follow-up (arrow top) in populations stratified by baseline and follow-up glucose tolerance status (6). DM, diabetes; NGT, normal glucose tolerance.
Figure 2
Figure 2
Illustration of coefficient of β-cell failure over time in relation to A1C (from UKPDS) (13).
Figure 3
Figure 3
Factors regulating β-cell mass (24).
See this image and copyright information in PMC

References

    1. Stratton IM, Adler AI, Neil HA, Matthews DR, Manley SE, Cull CA, Hadden D, Turner RC, Holman RR: Association of glycaemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35): prospective observational study BMJ 2000; 321: 405– 412 - PMC - PubMed
    1. Nichols GA, Hillier TA, Brown JB: Progression from newly acquired impaired fasting glucose to type 2 diabetes. Diabetes Care 2007; 30: 228– 233 - PMC - PubMed
    1. Meigs JB, Muller DC, Nathan DM, Blake DR, Andres R: Baltimore Longitudinal Study of Aging The natural history of progression from normal glucose tolerance to type 2 diabetes in the Baltimore Longitudinal Study of Aging. Diabetes 2003; 52: 1475– 1484 - PubMed
    1. Ferrannini E, Nannipieri M, Williams K, Gonzales C, Haffner SM, Stern MP: Mode of onset of type 2 diabetes from normal or impaired glucose tolerance. Diabetes 2004; 53: 160– 165 - PubMed
    1. Weyer C, Tataranni PA, Bogardus C, Pratley RE: Insulin resistance and insulin secretory dysfunction are independent predictors of worsening of glucose tolerance during each stage of type 2 diabetes development. Diabetes Care 2001; 24: 89– 94 - PubMed

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