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Review
. 2009 Nov;32 Suppl 2(Suppl 2):S174-7.
doi: 10.2337/dc09-S305.

Where does insulin resistance start? The brain

Uberto Pagotto  1
Affiliations
Review

Where does insulin resistance start? The brain

Uberto Pagotto. Diabetes Care. 2009 Nov.
No abstract available

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Figures

Figure 1
Figure 1
The upper part of the figure shows the mechanism by which insulin acting at the brain level, and precisely at the hypothalamus, may modulate glycemia by reducing food intake. The lower part shows how insulin receptor signaling is required for the maintenance of normal glucose homeostasis. KATP channels in hypothalamic neurons are activated by insulin and influence hepatic glucose production, an effect that is mediated by the autonomous nervous system.
Figure 2
Figure 2
The consequences of central insulin resistance are depicted. An impairment of insulin signaling in the CNS may lead to hyperphagia, weight gain, and consequently to hyperinsulinemia (upper part), but also to a dysregulation of plasma glucose levels for the potentiation of gluconeogenesis.
See this image and copyright information in PMC

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