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Review
. 2010;54(2-3):397-408.
doi: 10.1387/ijdb.082758ea.

Estrogen regulation of placental angiogenesis and fetal ovarian development during primate pregnancy

Eugene D Albrecht  1 , Gerald J Pepe
Affiliations
Review

Estrogen regulation of placental angiogenesis and fetal ovarian development during primate pregnancy

Eugene D Albrecht et al. Int J Dev Biol. 2010.

Abstract

During human and nonhuman primate pregnancy, an extensive blood vessel network is established within the villous placenta to support fetal growth and follicles develop within the fetal ovary to provide a pool of oocytes for reproductive function in adulthood. These two important developmental events occur in association with a progressive increase in placental estrogen production and levels. This review will describe the developmental processes required for placental vascularization and fetal follicular maturation and recent studies which show that estrogen has an important role in regulating these events.

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Figures

Fig. 1
Fig. 1. Estrogen regulation of placental angiogenesis and fetal ovarian development during primate pregnancy
See this image and copyright information in PMC

References

    1. Abbott DH, Padmanabhan V, Dumesic DA. Contributions of androgen and estrogen to fetal programming of ovarian dysfunction. Reprod Biol Endocrinol. 2006;4:17. - PMC - PubMed
    1. Aberdeen GW, Wiegand SJ, Bonagura TW, Pepe GJ, Albrecht ED. Vascular endothelial growth factor mediates the estrogen-induced breakdown of tight junctions between and increase in proliferation of microvessel endothelial cells in the baboon endometrium. Endocrinology. 2008;149:6076–6083. - PMC - PubMed
    1. Ahmad S, Ahmed A. Elevated placental soluble vascular endothelial growth factor receptor-1 inhibits angiogenesis in preeclampsia. Circ Res. 2004;95:884–891. - PubMed
    1. Ahmad S, Ahmed A. Antiangiogenic effect of soluble vascular endothelial growth factor receptor-1 in placental angiogenesis. Endothelium. 2005;12:89–95. - PubMed
    1. Ahmed A, Dunk C, Ahmad S, Khaliq A. Regulation of placental vascular endothelial growth factor (VEGF) and placenta growth factor (PIGF) and soluble Flt-1 by oxygen: a review. Placenta (Suppl A) 2000;21:S16–S24. - PubMed

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