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Comment
. 2009 Nov 6;16(5):363-4.
doi: 10.1016/j.ccr.2009.10.008.

Mst out and HCC in

Bin Zhao  1 , Qunying Lei, Kun-Liang Guan
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Free article
Comment

Mst out and HCC in

Bin Zhao et al. Cancer Cell. .
Free article

Abstract

Mst1 and Mst2 are key components of the Hippo tumor suppressor pathway. In this issue, Zhou et al. (2009) reported that Mst1/2 ablation leads to hepatocellular carcinomas. Unexpectedly, Mst1/2 may activate another kinase besides Lats1 and Lats2 to phosphorylate YAP, and the role of Mst1/2 in YAP regulation is cell type dependent.

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