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. 1977 Sep;74(9):4025-8.
doi: 10.1073/pnas.74.9.4025.

Amyloid protein SAA is associated with high density lipoprotein from human serum

E P Benditt, N Eriksen

Amyloid protein SAA is associated with high density lipoprotein from human serum

E P Benditt et al. Proc Natl Acad Sci U S A. 1977 Sep.

Abstract

Human serums contain a protein antigenically related to protein AA, the principal protein of a major class of amyloid substance. The serum antigen, SAA, occurs mainly in a high molecular weight form, 1 to 2 X 10(5). This work shows that the bulk of the SAA sediments at density 1.12 g/cm3 and floats at density 1.21 g/cm3, as does the high density lipoprotein HDL3. SAA is associated with the apolipoproteins ApoA-I and ApoA-II. The total cholesterol:total protein ratio of the fraction with density 1.12-1.21 g/cm3 is 0.2:1, consistent with that of SAA constituent of the HDL3 fraction into low molecular weight species of the order of 13,000. The quantity of SAA may vary from 0.1% or more of the total protein of HDL3.

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References

    1. Arch Pathol Lab Med. 1977 May;101(5):225-9 - PubMed
    1. FEBS Lett. 1976 Oct 15;69(1):111-5 - PubMed
    1. J Lab Clin Med. 1977 May;89(5):1092-1104 - PubMed
    1. J Exp Med. 1976 Dec 1;144(6):1679-82 - PubMed
    1. Proc Natl Acad Sci U S A. 1977 Mar;74(3):837-41 - PubMed

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