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. 2010 Aug;16(8):1282-4.
doi: 10.1111/j.1469-0691.2009.03104.x. Epub 2009 Nov 2.

Detection of interleukin-2 in addition to interferon-gamma discriminates active tuberculosis patients, latently infected individuals, and controls

R Biselli  1 , S Mariotti, V Sargentini, I Sauzullo, M Lastilla, F Mengoni, V Vanini, E Girardi, D Goletti, R D' Amelio, R Nisini
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Free article

Detection of interleukin-2 in addition to interferon-gamma discriminates active tuberculosis patients, latently infected individuals, and controls

R Biselli et al. Clin Microbiol Infect. 2010 Aug.
Free article

Abstract

Effective control of tuberculosis (TB) includes discrimination of subjects with active TB from individuals with latent TB infection (LTBI). As distinct interferon (IFN)-gamma and interleukin (IL)-2 profiles of antigen-specific T-cells have been associated with different clinical stages and antigen loads in several viral and bacterial diseases, we analysed these cytokines in TB using a modified QuantiFERON-TB Gold In Tube test. Detection of IL-2 in addition to IFN-gamma distinguishes not only Mycobacterium tuberculosis-infected subjects from healthy controls, but also individuals with LTBI from active TB patients. This may help to improve diagnostic tests for TB.

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