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Comment
. 2009 Nov;16(11):1121-2.
doi: 10.1038/nsmb1109-1121.

Glycan terminator

James C Paulson, Christoph Rademacher
Comment

Glycan terminator

James C Paulson et al. Nat Struct Mol Biol. 2009 Nov.
No abstract available

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Figures

Figure 1
Figure 1
Structural relationships among the human sialyltransferase family. a) Homology dendrogram is shown for twenty members of the human siatlyltransferase family. Sialoside products produced by each of the four major subfamilies are shown in symbol form. b) CPK representation of pST3Gal-I highlighting the four ‘sialyl motifs’: large (L, cyan), small (S, red), 3 (3, green) and very small (VS, yellow). The bound acceptor ligand is highlighted in red. The postulated ‘lid’ domain consisting of a disordered loop located between the motifs 3 and VS is omitted. c) Localization of the sialylmotif regions in the primary sequence of pST3GalI highlighted using the same color-coding for the conserved motifs in panel b. d) Homology heat map highlighting regions of sequence conservation among all 20 members of the sialyltransferase family. relative to hST3GalI. Insertions in other sialyltransferases relative to hST3Gal I are omitted to maintain comparisons relative the sialylmotifs illustrated in panel c.
See this image and copyright information in PMC

Comment on

  • Structural insight into mammalian sialyltransferases.
    Rao FV, Rich JR, Rakić B, Buddai S, Schwartz MF, Johnson K, Bowe C, Wakarchuk WW, Defrees S, Withers SG, Strynadka NC. Rao FV, et al. Nat Struct Mol Biol. 2009 Nov;16(11):1186-8. doi: 10.1038/nsmb.1685. Epub 2009 Oct 11. Nat Struct Mol Biol. 2009. PMID: 19820709

References

    1. Karlsson KA. Meaning and therapeutic potential of microbial recognition of host glycoconjugates. Mol Microbiol. 1998;29:1–11. - PubMed
    1. Taylor ME, Drickamer K. Paradigms for glycan-binding receptors in cell adhesion. Curr Opin Cell Biol. 2007;19:572–577. - PubMed
    1. Crocker PR, Paulson JC, Varki A. Siglecs and their roles in the immune system. Nat Rev Immunol. 2007;7:255–266. - PubMed
    1. Jeanneau C, Chazalet V, Auge C, et al. Structure-function analysis of the human sialyltransferase ST3Gal I: role of n-glycosylation and a novel conserved sialylmotif. J Biol Chem. 2004;279:13461–13468. - PubMed
    1. Datta AK. Comparative sequence analysis in the sialyltransferase protein family: analysis of motifs. Curr Drug Targets. 2009;10:483–498. - PubMed

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