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Review
. 2010 May;54(5):663-9.
doi: 10.1002/pbc.22265.

Hepato-biliary late effects in survivors of childhood and adolescent cancer: a report from the Children's Oncology Group

Sharon Castellino  1 , Andrew Muir, Ami Shah, Sheila Shope, Kevin McMullen, Kathy Ruble, Ashley Barber, Andrew Davidoff, Melissa M Hudson
Affiliations
Review

Hepato-biliary late effects in survivors of childhood and adolescent cancer: a report from the Children's Oncology Group

Sharon Castellino et al. Pediatr Blood Cancer. 2010 May.

Abstract

Curative therapy for childhood and adolescent cancer translates to 1 in 640 young adults being a survivor of cancer. Although acute hepato-biliary toxicity occurs commonly during pediatric cancer therapy, the impact of antineoplastic therapy on long-term liver health in childhood/adolescent cancer survivors is unknown. This article reviews the medical literature on late liver dysfunction following treatment for childhood/adolescent cancer. We also outline the Children's Oncology Group (COG) guidelines for screening and follow-up of hepato-biliary sequelae. As the population of survivors grow and age, vigilance for risks to hepatic health needs to continue based on specific exposures during curative cancer therapy.

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Conflict of interest statement

Conflict of Interest Disclosure: The authors report no affiliations or no financial interests relevant or important to the subject matter discussed.

References

    1. Hewitt M, Weiner S, Simone J, editors. Childhood cancer survivorship:improving care and quality of life. Washington, DC: National Academies Press; 2003. - PubMed
    1. Floyd J, Mirza I, Sachs B, et al. Hepatotoxicity of chemotherapy. Semin Oncol. 2006;33(1):50–67. - PubMed
    1. Rodriguez-Frias EA, Lee WM. Cancer chemotherapy II: atypical hepatic injuries. Clin Liver Dis. 2007;11(3):663–676. viii. - PubMed
    1. Socie G, Stone JV, Wingard JR, et al. Long-term survival and late deaths after allogeneic bone marrow transplantation. Late Effects Working Committee of the International Bone Marrow Transplant Registry. N Engl J Med. 1999;341(1):14–21. - PubMed
    1. Landier W, Bhatia S, Eshelman DA, et al. Development of risk-based guidelines for pediatric cancer survivors: the Children’s Oncology Group Long-Term Follow-Up Guidelines from the Children’s Oncology Group Late Effects Committee and Nursing Discipline. J Clin Oncol. 2004;22(24):4979–4990. - PubMed

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