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. 1991 Feb;180(2):617-24.
doi: 10.1016/0042-6822(91)90075-m.

Structural characteristics of the M2 protein of influenza A viruses: evidence that it forms a tetrameric channel

R J Sugrue  1 , A J Hay
Affiliations

Structural characteristics of the M2 protein of influenza A viruses: evidence that it forms a tetrameric channel

R J Sugrue et al. Virology. 1991 Feb.

Abstract

The evidence presented shows that the M2 protein of influenza A viruses exists in infected cells as a homotetramer composed of two disulfide-linked dimers held together by noncovalent interactions. The amphiphilic nature of the transmembrane alpha-helical domain is consistent with the protein forming a transmembrane channel with which amantadine, the specific anti-influenza A drug, interacts. Together these features provide a structural basis for the hypothesis that M2 has a proton translocation function capable of regulating the pH of vesicles of the trans-Golgi network, a role important in promoting the correct maturation of the hemagglutinin glycoprotein.

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References

    1. Bean W.J., Threlkeld S.C., Webster R.G. Biologic potential of amantadine-resistant influenza A virus in an avian model. J. Infect. Dis. 1989;159:1050–1056. - PubMed
    1. Belshe R.B., Hall-Smith M., Hall C.B., Betts R., Hay A.J. Genetic basis of resistance to rimantadine emerging during treatment of influenza virus infection. J. Virol. 1988;62:1508–1512. - PMC - PubMed
    1. Belshe R.B., Hay A.J. Drug resistance and the mechanisms of action on influenza A virus. J. Respir. Dis. Suppl. 1989:S52–S61.
    1. Bukrinskaya A.G., Vorkunova N.K., Pushkarskaya N.L. Vol. 60. 1982. Uncoating of a rimantadine-resistant variant of influenza virus in the presence of rimantadine; pp. 61–66. (J. Gen. Virol.). - PubMed
    1. Charnet P., Labarca C., Leonard R.J., Vogelaar N.J., Czyzyk L., Gouin A., Davidson N., Lester H.A. An open-channel blocker interacts with adjacent turns of a-helices in the nicotinic acetylcholine receptor. Neuron. 1990;4:87–95. - PubMed

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