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. 2010 Apr;60(2):235-7.
doi: 10.1016/j.cryobiol.2009.10.012. Epub 2009 Nov 4.

Resveratrol and ascorbic acid prevent DNA damage induced by cryopreservation in human semen

Cátia S Branco  1 , Márcia E Garcez, Fábio F Pasqualotto, Bernardo Erdtman, Mirian Salvador
Affiliations
Free article

Resveratrol and ascorbic acid prevent DNA damage induced by cryopreservation in human semen

Cátia S Branco et al. Cryobiology. 2010 Apr.
Free article

Abstract

Cryopreservation of human semen can cause DNA damages, which compromise the fertilization and normal embryo development. The present study showed that the antioxidant resveratrol prevents these damages both in fertile and infertile men. The addition of ascorbic acid before cryopreservation can reduce DNA damages only in infertile men. Although further studies are needed, the present work showed that resveratrol could be considered in human cryopreservation procedures to avoid/minimize DNA damages and preserve sperm integrity.

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